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November 2015

Volume 1  Issue 1

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Research Article 

Effects of Aerobic Exercise Training on S-Klotho in Young and Elderly

Moran Saghiv*, Ehud Goldhammer, Michael Sagiv, David Ben-Sira

Age causes structural and functional changes in skeletal, cardiac and oxygen delivery ability in humans. No matter what  genes one has inherited, the body is continuously undergoing complex biochemical reactions. Some of these reactions cause damage and, ultimately, aging in the body. However, genetic component of longevity and aging helps a person to live longer. Because of its complexity, the aging process takes us into the area of integrative biology.

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Research Article 

Effects of Anaerobic Exercise Training on S-Klotho in Young and Elderly

Moran Saghiv*, Michael Sagiv, David Ben-Sira

Anaerobic bouts can be limited by lactic acid levels in the blood and active muscles. It is characterized by exposing the subjects to a very high degree of sudden strenuous all-out exercise, Thus, increasing insulin-like growth factor-1 (IGF-1) levels in the blood, primarily due to a substantial major increase in plasma catecholamine concentrations. When reactive oxygen species production overwhelms the protection and repair mechanisms, the net effect is oxidative stress and oxidative damage of DNA, membrane lipids, and proteins.

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Research Article 

Comparison between aerobic and anaerobic training influence on s-klotho blood levels following 60 min aerobic bout

Moran Saghiv*, David Ben-Sira, Michael Sagiv

Soluble-Klotho (s-Klotho) is a powerful longevity protein that has been linked to the prevention of muscle atrophy, osteopenia, and cardiovascular disease. S-Klotho is a transmembrane protein which can be cleaved, shed and act as a circulating hormone. Strenuous all-out exercise training increase lactic acid levels in the blood and active muscles and increase insulin- like growth factor-1 (IGF-1) levels in the blood, primarily due to a substantial major increase in plasma catecholamine concentrations.

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Editorial 

The Effect of Proteins in Maternal Diet on Fetal and Early Post-Natal Development of Food Intake Regulation in Hypothalamus (A Short Conversation)

Alireza Jahan-mihan*

Altered fetal development of food intake regulatory system in hypothalamus can contribute to the etiology of obesity in later life. Both protein content and protein source in maternal diet during gestation and lactation affect hypothalamic development of food intake regulatory system in fetus and neonate. Components of the central neural network for regulating food intake are present before birth in rodents and higher-order mammals. The neuronal circuitry is not fully developed until 16 days after birth in rodents which is quite different from human and sheep.

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Research Article

Changes in Cytokines Status of Patients with Recurrent Pulmonary Tuberculosis Receiving Chemotherapy

Dmytro O. Butov*, Mykhailo M. Kuzhko, Olga S. Shevchenko, Hanna L. Stepanenko, Tetyana S. Butova

Tuberculosis (TB) occupies one of the leading positions among the most common infectious diseases. Despite the stabilization of morbidity, there is a difficult epidemiological situation with TB due to the increasing of proportion of severe advanced forms and rate growth of relapse in the total incidence of TB. In addition, the issue of pulmonary tuberculosis relapse has been remaining of great importance due to the consistently high incidence of tuberculosis reactivation in patients with active tuberculosis history for many years.

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Research Article

Validation of a Non-Transmitting Memory Belt for Measuring Heart Rate Variability

Stefan Sammito*, Irina Böckelmann

Measuring physical activity is an established method for assessing physical strain. A correlation between cardiac output per minute and respiratory minute volume and the heart rate is known. Therefore, the latter measurement is also suitable to determine the individual load of physical activity f.e. during work. The Holter ECG system with its wire-lead data transmission has been established as the gold standard for measuring the heart rate.

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